Usor:Andreas Raether/compendium neurologiae/Tumores

Lymphomata systematis nervosi centralis

Lymphomata non Hodgkiniana primaria

• Distributio aetatis: medianum apud aegrotos non immunosupressos: 60-70 annos natos
• Praedispositio: Syndromata deficientiis systematis immunitatis innatis (Syndroma Wiskott-Aldrich, Ataxia teleangiectatica et al.), suppressio immunitatis acquisita (SIDA, transplantatio organorum [periculo centies aucto], cytostatica); morbi autoimmunitatis

Pathologia

Imprimis lymphomata cellularum B (magnocellularia, diffusa), rarissime cellularum T; foci intracraniales imprimis supratentoriali (52-82%), praecipue periventriculare, solitaria (50-57%) aut multiplices, satus diffus et leptomeningealis (25-75%, autopsia ad 100%); invasio uveae vel corporis vitrei (10-18%); sationes systemicae (ad 10% cum recidivo; investigationibus molecularibus etiam diagnosi prima in causarum 10% satio systemica et subclinica).

Imago clinica

Signa neurologica focalia (>50%), psychosyndroma (ca. 50%), Signa pressionis cerebralis aucta (ca. 30. %), imbecillitates nervorum cranialium (ca. 30%), diminutio visus (satu uveae vel corporis vitrei, de consuetudine clinice non apparens).

Iconismus diagnosticus

• Scanner: praecipue laesiones multiplices periventriculares, native potius hyperdensae
• IRM: T1 hypo-, vel isointensae

Therapia

• Therapia pressionis cerebralis (ante biopsiam)
• Steroida (post biopsiam)
• Chemotherapia
• Radiotherapia